Isocyanate-functional prepolymer for a biologically degradable fabric adhesive

A method for closing or bonding cell tissue comprising providing a tissue adhesive system comprising a tissue adhesive comprising a component A), an isocyanate functional prepolymer obtained by reacting an H functional starter compound having at least one Zerewitinoff active H atom with an alkylene oxide and a comonomer to a preliminary stage bearing hydroxyl groups, wherein said comonomer is selected from the group consisting of lactides, glycolides, cyclical dicarboxylic acid anhydrides, and mixtures thereof and wherein said comonomer is integrated through statistical copolymerization into the polymer chain(s) of a preliminary stage bearing hydroxyl groups, and

• reacting the preliminary stage bearing hydroxyl groups from step a) with a polyfunctional isocyanate to an isocyanate functional prepolymer,
• and a component B), an amino functional aspartic acid ester of
• formula (II)
• wherein R1, R2, R3 are equal or different organic radicals having no Zerewitinoff active H atoms,
• and/or
• a reaction product of the isocyanate functional prepolymer A) with amino functional aspartic acid esters B) as component C),
• and applying the tissue adhesive system to the cell tissue to be bonded.