US 2016/0256594 A1 · EMULSIONS OR MICROEMULSIONS FOR USE IN ENDOSCOPIC MUCOSAL RESECTIONING AND/OR ENDOSCOPIC SUBMUCOSAL DISSECTION

Abstract

The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.

Claims24

Dependent claims

A pharmaceutical composition in the form of an emulsion or a microemulsion comprising:

(a) an aqueous phase;
(b) an oily phase;
(c) at least one surfactant;
(d) at least one of poloxamer 188, poloxamer 407 or a mixture of poloxamer 188 and poloxamer 407;
and
(e) at least one physiologically acceptable excipient;
wherein said at least one of poloxamer 188, polyoxamer 407 or a mixture of poloxamer 188 and poloxamer 407 is present in an amount below the critical gelation concentration (CGC), and wherein said composition remains in liquid phase at a temperature between about 5° C. and about 40° C. in vitro.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/154,857Filed 13 May 2016

Priority

IT MI2013A00192420 Nov 2013

Published

8 Sep 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 47/34
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: macromolecular compounds obtained otherwise than by reactions only…
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/107
Dispersions; Emulsions: emulsions ; Emulsion preconcentrates; Micelles
A61K 9/1075
Emulsions ; Emulsion preconcentrates; Micelles: microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of…

Family

Application14/546,925Continuation · filed 18 Nov 2014

Application14/950,525Continuation · filed 24 Nov 2015

Application15/154,857Continuation

US 2015/0141526 A1Published application

US 2016/0074554 A1Published application

US 9,226,996 B2Related patent

US 9,364,580 B2Related patent

US 9,522,216 B2Related patent

US 2016/0256594 A1This patent

From the US filing history. Foreign family members aren’t listed.

Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection

Life of this patent

Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection

Life of this patent

Abstract

Claims24