Wound dressings, methods and apparatus for making same and storage and use thereof
AssigneeReddress Ltd.
InventorsAlon Kushnir, Igal Kushnir
Life of this patent
Estimating the term…
Abstract
Provided is a wound dressing prepared from whole blood that is clotted ex vivo to form a sheet of clotted blood that is applied onto the skin over a sight of skin injury.
Claims16
1-19. (canceled)
A kit or assembly for preparation of a wound dressing, the kit comprising:
- (a) a sterile container adapted to receive a volume of whole blood;
- (b) anticoagulant;
- (c) coagulation initiator;
- (d) a tray or support matrix for receiving said volume of whole blood and permitting it to spread and form whole blood clot and for preparing a wound dressing comprising the clot.
A kit or assembly according to claim 1, comprising a support matrix that can be accommodated within the tray whereupon the clot of whole blood is formed.
A kit or assembly according to claim 1, wherein said anticoagulant includes at least one substance selected from the group consisting of ethylenediaminetetraacetic acid (EDTA), ethylene glycol tetraacetic acid (EGTA), a citrate, Heparin and oxalate.
A kit or assembly according to claim 1, wherein said coagulation initiator is selected from the group consisting of Ca2+, Mg2+, Kaolin, negatively charged phospholipid (PL) and protamine sulfate.
A method of preparing a wound dressing, the method comprising:
- (a) collecting a volume of whole blood;
- (b) clotting said whole blood to form a clot ex vivo;
- and
- (c) forming a wound dressing comprising the whole blood clot.
A method according to claim 5, comprising cutting a portion of said clot to dimensions suitable for dressing a specific wound.
A method according to claim 5, comprising providing a support structure upon which said clot forms.
A method of producing a biological dressing comprising,
- (a) spreading a unit of whole blood to cover an area;
- and
- (b) allowing the whole blood to clot to thereby form a clotted whole blood sheet.
A method according to claim 8, comprising adding a coagulation initiator prior to said spreading.
A method according to claim 9, wherein said coagulation initiator is selected to neutralize an activity of an anticoagulant in said unit.
A method according to claim 8, wherein said spreading is on a mesh which becomes embedded in said clot.
A method according to claim 8, wherein said clot is adhered to a support matrix.
A bank of biological dressings, the bank comprising:
- (a) a plurality of sterile sheets of clotted whole blood prepared in accordance with the method of claim 8;
- and
- (b) cross compatibility information for each of said sheets.
A wound dressing prepared by combining whole blood and a support matrix and permitting the whole blood to clot upon the support matrix.
A wound dressing according to claim 14, wherein the support matrix is gauze.
Dependencies are inferred from the claim text.