Heat-induced radiochemical labeling of an iron oxide nanoparticle
AssigneeThe General Hospital Corporation
InventorsJason Philip Holland, Lee Josephson
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Abstract
A method of synthesizing a radiolabeled nanoparticle. The method includes heating a solution including an iron oxide nanoparticle and at least one radioactive metal ion to bind the iron oxide nanoparticle and the at least one radioactive metal ion, thereby forming the radiolabeled nanoparticle. The method further includes adding a quenching agent to the solution to complex with non-bound radioactive metal ions remaining in the solution. The method further includes separating the complexed quenching agent from the radiolabeled nanoparticle.
Claims23
A method of synthesizing a radiolabeled nanoparticle, the method comprising:
- (i) heating a solution including an iron oxide nanoparticle and at least one radioactive metal ion to bind the iron oxide nanoparticle and the at least one radioactive metal ion, thereby forming the radiolabeled nanoparticle;
- (ii) adding a quenching agent to the solution to complex with non-bound radioactive metal ions remaining in the solution;
- and
- (iii) separating the complexed quenching agent from the radiolabeled nanoparticle.
A method of synthesizing a radiolabeled nanoparticle, the method comprising:
- heating a solution including a polymer-coated iron oxide nanoparticle and at least one radioactive metal ion to bind the iron oxide nanoparticle and the at least one radioactive metal ion, thereby forming the radiolabeled nanoparticle.
A radiolabeled nanoparticle comprising:
- a polymer-coated iron oxide nanoparticle bonded to a radioactive metal ion, the bonding being configured to withstand an addition of a quenching agent.
A method of removing a radioactive metal ion from solution, the method comprising:
- (i) heating a solution including an iron oxide nanoparticle and at least one radioactive metal ion to bind the iron oxide nanoparticle and the at least one radioactive metal ion;
- (ii) adding a quenching agent to the solution to complex with non-bound radioactive metal ions remaining in the solution;
- and
- (iii) removing the complexed quenching agent from the solution.
A method of imaging of macrophages using a heat induced radiolabeled nanoparticle, the method comprising:
- injecting a polymer-coated iron oxide nanoparticle bonded to a radioactive metal ion into a subject such that the polymer-coated iron oxide nanoparticle bonded to a radioactive metal ion is internalized by the macrophage, the bonding between the polymer-coated iron oxide nanoparticle and the radioactive metal ion being configured to withstand an addition of a quenching agent;
- and
- using magnetic resonance imaging and radioactive imaging to detect and image the macrophage.
Dependencies are inferred from the claim text.