US 2016/0256568 A1Published application

Compositions and methods for delivering messenger rna

AssigneeProtiva Biotherapeutics, Inc.

InventorsJames HEYES, Lorne R. PALMER, Stephen P. REID, Edward D. YAWORSKI, Ian MACLACHLAN, Mark WOOD, Alan D. MARTIN

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Abstract

The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provided cationic lipids that are useful for preparing the compositions of the invention.

Claims17

Dependent claims

A lipid particle comprising:

(a) one or more mRNA molecule(s) that each encode a protein;
(b) a cationic lipid or a salt thereof comprising from about 30 mol % to about 50 mol % of the total lipid present in the particle;
(c) a mixture of a phospholipid and cholesterol or a derivative thereof comprising from about 47 mol % to about 69 mol % of the total lipid present in the particle;
and
(d) a PEG-lipid conjugate comprising from about 1 mol % to about 3 mol % of the total lipid present in the particle.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/153,291Filed 12 May 2016
Priority: 23 Jul 2013
Published: 8 Sep 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification19 codes

A61K 48/0008
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy:…
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/1271
Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant: non-conventional liposomes,…
A61K 9/1272
Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers: comprising non-phosphatidyl surfactants as…

Family

Application61/857,573Us provisional application · filed 23 Jul 2013
Application61/943,856Us provisional application · filed 24 Feb 2014
Application14/907,181Continuation · filed 22 Jan 2016
Application15/153,291Continuation
US 2016/0151284 A1Published application
US 2016/0256568 A1This patent

From the US filing history. Foreign family members aren’t listed.

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