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US 2016/0256561 A1Published application
Pyrrolobenzodiazepine-antibody conjugates
AssigneesMedImmune, LLC, Adc Therapeutics SA
InventorsPhilip Wilson Howard, Patricius Hendrikus Cornelis Van Berkel
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Abstract
Conjugates of specific PBD dimers with an antibody that that binds to HER2, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.
Claims15
A conjugate of formula
- ConjB:
- ConjC
- or
- ConjDE:
- wherein:
- Ab is an antibody that binds to HER2, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.
3 more elements
-12. (canceled)
(canceled)
Dependencies are inferred from the claim text.