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US 2016/0256560 A1Published application
Environmentally Sensitive Compositions
AssigneesRhode Island Board of Governors for Higher Education, Yale University
InventorsYana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
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Abstract
An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
Claims22
An environmentally sensitive composition comprising
- a pH triggered membrane sequence comprising at least 8 amino acids,
- at least 6 of the 8 amino acids of said membrane sequence are non-polar, said non-polar amino acids being contiguous, and
- at least one of the 8 amino acids of said membrane sequence is protonatable, and
- the peptide has a higher affinity to a membrane lipid bilayer at pH5.0 compared to at pH 8.0, wherein said composition does not comprise the amino acid sequence of SEQ ID NO:1.
1 more element
Dependencies are inferred from the claim text.