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US 2016/0256559 A1Published application
Sterically stabilized cationic nanocarrier, kits and method of use
AssigneeThe Board of Trustees of the University of Illinois
InventorsHayat Onyuksel, Fatima A. Khaja
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Abstract
A compound composed of a phospholipid and basic amino acid residues is provided as is a sterically stabilized phospholipid nanocarrier containing the compound and use of the same in passive and targeted delivery of negatively charged therapeutic agents encapsulated within the nanocarrier.
Claims26
A sterically stabilized nanocarrier comprising a PEGylated phospholipid complexed with one or more cationic phospholipids, wherein said sterically stabilized nanocarrier has a particle size of about 10 nm to about 100 nm.
A compound having the structure of Formula I:
- wherein R is a linear chain of between 1 and 10 basic amino acid residues and each R1 is independently a saturated or unsaturated acyl chain of between 16 and 18 carbon atoms.
A kit comprising
- (a) a compound having the structure of Formula I:
- wherein R is a linear chain of between 1 and 10 basic amino acid residues and each R1 is independently a saturated or unsaturated acyl chain of between 16 and 18 carbon atoms, and
- (b) a PEGylated phospholipid.
Dependencies are inferred from the claim text.