Stabilizing agent for pharmaceutical proteins
AssigneeOctapharma AG
InventorsElsa Ivarsson, Josefin Knutsson, Brita Rippner, Ulrika Nilsson, Irène Agerkvist
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Abstract
A method for stabilising a human blood protein or human blood plasma protein with a molecular weight of >10 KDa by adding melezitose to a solution comprising the human blood protein or human blood plasma protein with a molecular weight of >10 KDa.
Claims18
A method for stabilising a human blood protein or human blood plasma protein with a molecular weight of >10 KDa by adding melezitose to a solution comprising the human blood protein or human blood plasma protein with a molecular weight of >10 KDa.
A composition comprising a human blood protein or human blood plasma protein with a molecular weight of >10 KDa and melezitose.
Use of melezitose for stabilisation of a human blood protein or human blood plasma protein with a molecular weight of >10 KDa, in particular in an in-process stabilisation, in a lyophilisation process, in solution, during purification, and production in particular in cell culture;
- or for long term stabilisation in particular to improve shelf-life, wherein the long-term is at least 6 months, in particular at least 12 months, more particular at least 18 months, still more particular 24 months or 36 months.
Dependencies are inferred from the claim text.