Transdermal colloidal solution agent
AssigneeMedrx Co., Ltd.
InventorKeiko YAMASAKI
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Abstract
Disclosed is a transdermal absorptive liquid preparation in which a medicament or a salt thereof is colloidally dispersed in propylene glycol or a propylene glycol-containing solvent, whose transdermal permeability of the medicament is excellent, problem of skin irritation is reduced. This transdermal absorptive liquid formulation has a mode of particle diameter at around 100 nm, and an average particle size of 50 to 500 nm. This transdermal absorptive liquid formulation makes marked improvement in the transdermal permeability by further containing an absorption promoter such as triethanolamine.
Claims17
A transdermal absorptive colloidal liquid formulation comprising a medicament or a salt thereof colloidally dispersed in propylene glycol or a propylene glycol-containing solvent in the presence of phosphatidyl choline.
A transdermal absorptive liquid formulation comprising a medicament or a salt thereof, propylene glycol, phosphatidyl choline, and a higher alcohol.
Dependencies are inferred from the claim text.