Hexapeptide and uses thereof
OwnerAldo MANCINIinventor
Life of this patent
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Abstract
The present invention concerns a hexapeptide and its medical and/or diagnosis uses, in particular for the diagnosis and/or treatment of cancer.
Claims31
1- A peptide consisting of the sequence AVCGTG (SEQ ID No. 1).
2- The peptide according to claim 1 being conjugated to a molecule.
3- The peptide according to claim 2 wherein the molecule is selected from the group consisting of:
- a therapeutic agent, a dye, a chelating agent, an antigen, a peptide, a metal, a λ or β emitting radioactive isotope, and an antibody molecule.
4- The peptide according to claim 3 wherein the therapeutic agent is selected from the group consisting of:
- chemotherapeutic agent, antibiotic agent, anti-inflammatory agent, anthistamine agent, antiparasitic agent, antiviral agent, and antitumor antibody.
5- The peptide according to claim 4 wherein the chemotherapeutic agent is selected from the group consisting of:
- cisplatin, idarubicin, epirubicin, cytarabine, farmarubicin, and etoposside.
6- The peptide according to claim 4 wherein the antibiotic agent is selected from the group consisting of:
- b-lactam, and quinolone antibiotics.
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12- A method for inducing an immunological response in a patient comprising administering a peptide according to claim 1 thereto.
13- A method for producing antibodies in a patient comprising administering a peptide according to claim 1 thereto.
14- A molecule selected from the group consisting of:
- a nucleotide sequence coding for the peptide consisting of the sequence AVCGTG (SEQ ID No. 1) or ortolog nucleotide sequence thereof;
- a vector comprising said nucleotide sequence;
- and
- a host cell genetically engineered expressing said peptide.
15- A composition comprising a molecule and acceptable excipients wherein the molecule is selected from the group consisting of:
- a) peptide consisting of the sequence AVCGTG (SEQ ID No. 1);
- b) a nucleotide sequence coding for the peptide consisting of the sequence AVCGTG (SEQ ID No. 1) or ortholog nucleotide sequence thereof;
- c) a vector comprising said nucleotide sequence;
- and
- d) a host cell genetically engineered expressing said peptide.
16- The composition according to claim 15 wherein the peptide is conjugated to a molecule.
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23- Kit for the diagnosis of a tumor comprising the peptide according to claim 1.
24- A method for the treatment of a tumor in a patient, comprising administering a composition according to claim 15 to said patient.
25- The method of claim 24, wherein the tumor is a leukemia.
26- A method for the treatment of a tumor in a patient, comprising administering the peptide conjugated to a molecule of claim 2 to said patient.
27- The method of claim 26, wherein the tumor is a leukemia.
28- A method transporting a molecule to a target site in a patient, comprising administering the peptide conjugated to a molecule of claim 2 to said patient.
29- The method of claim 26, wherein the target site is selected from the group consisting of:
- tumor cell, leukocyte, gamete, normal cell, stem cell and bacteria.
30- A method for inducing an immunological response in a patient comprising administering the peptide conjugated to a molecule of claim 2 to said patient thereto.
31- A method for producing antibodies in a patient comprising administering the peptide conjugated to a molecule of claim 2 to said patient thereto.