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US 2016/0256516 A1Published application
Phosphorylcholine Conjugates and Uses Thereof
AssigneeTpcera Ltd.
InventorsYehuda Shoenfeld, Miriam Blank
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Abstract
The present invention provides phosphorylcholine conjugates and pharmaceutical compositions comprising same for the prevention or treatment of autoimmune diseases. In particular, the conjugates of the present invention are effective in treating autoimmune diseases associated with pathological inflammation.
Claims20
A phosphorylcholine-conjugate, comprising:
- at least one phosphorylcholine derivative attached to at least one tuftsin derivative, the tuftsin derivative comprising tuftsin attached to a plurality of amino acids, the plurality comprising a first amino acid attached to a second amino acid;
- wherein the first amino acid is selected from the group consisting of glycine, alanine, leucine, valine, arginine, histidine, lysine, serine, threonine, asparagine, glutamine, isoleucine, methionine, and non-natural, non-charged and non-polar amino acids;
- and
- wherein the second amino acid is selected from the group consisting of tyrosine and histidine.
1 more element
A method for treating an autoimmune disease in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising a phosphorylcholine-conjugate;
- wherein the phosphorylcholine-conjugate comprises at least one phosphorylcholine derivative attached to at least one tuftsin derivative, the tuftsin derivative comprising tuftsin attached to a plurality of amino acids, the plurality comprising a first amino acid attached to a second amino acid,
- wherein the first amino acid is selected from the group consisting of glycine, alanine, leucine, valine, arginine, histidine, lysine, serine, threonine, asparagine, glutamine, isoleucine, methionine, and non-natural, non-charged and non-polar amino acids, and
- wherein the second amino acid is selected from the group consisting of tyrosine and histidine.
Dependencies are inferred from the claim text.