Compositions and methods for prediction and treatment of human cytomegalovirus infections

A method for identifying a subject as susceptible to or likely to develop a human cytomegalovirus infection comprising the steps of:

• a. obtaining a biological sample from the subject;
• b. performing an assay on the sample obtained from the subject to identify a mutation in NOD2;
• and
• c. identifying the subject as susceptible to likely to develop human cytomegalovirus infection if the NOD2 mutation is identified.

A method for treating a subject having a human cytomegalovirus infection comprising the steps of:

• d. obtaining a biological sample from the subject;
• e. performing an assay on the sample obtained from the subject to identify a mutation in NOD1 or NOD2;
• f. identifying the subject as susceptible to likely to develop human cytomegalovirus infection if the NOD1 and/or NOD2 mutation is identified;
• and
• g. treating the subject with one or more treatment modalities appropriate for a subject having or likely to develop human cytomegalovirus infection.