Allograft tolerance induction
AssigneeThe United States of America as represented by the Secretary of the Navy
InventorsThomas A. Davis, Khairul Anam, Eric A. Elster, Douglas K. Tadaki
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Abstract
A method inducing chimerism and allograft tolerance by co-infusion of stein/progenitor-like cells and donor cells, wherein the donor cells can be bone marrow cells. The method also comprises the conditioning comprising depletion of CD4+ and CD8+ T-cells and administration of low doses of anti-neoplastic drugs. The inventive method comprises an aspect wherein allograft tolerance is induced without systemically suppressing the immune system.
Claims19
A transplantation method comprising inducing allograft tolerance and chimerism by administering to a host one or more doses of human stem/progenitor-like cells and allogeneic donor cells, wherein said allogneic donor cells are, unprocessed bone marrow, low density bone marrow cells or side population stem cells, to a host, depleting of CD4+ and CD8+ cells and administering a nonmycloablative antineoplastic agent.
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