Methods of treatment
OwnerSumant S. CHUGHinventor
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Abstract
The present disclosure provides a biochemical basis of nephrotic syndrome and provides and explanation for the observed proteinuria and other effects. As a result, the present disclosure provides method for treating and/or preventing nephrotic syndrome as well as methods of alleviating symptoms associated with nephrotic syndrome. The present disclosure further provides methods for reducing proteinuria in nephrotic syndrome and other disease states as discussed herein.
Claims19
A method for modulating the sialylation of Angptl4 in a human subject, the method comprising the step of administering a therapeutically effective amount of a sialic acid, a sialic acid precursor or a combination of the foregoing to the subject, wherein the subject has an increased level of Angptl4.
A method for the treatment of a condition characterized by a hyposialylated form of Angptl4 in a human subject, said method comprising the step of administering a therapeutically effective amount of a sialic acid, a sialic acid precursor or a combination of the foregoing to the subject, wherein the subject has non-reduced levels of sialic acid production.
Dependencies are inferred from the claim text.