Abuse-resistant controlled-release opioid dosage form

A method of preventing abuse of an oral opioid pharmaceutical composition, comprising providing a therapeutically effective amount of an oral controlled release pharmaceutical composition comprising:

• oxycodone and naloxone,
• wherein the oxycodone and the naloxone are present in the pharmaceutical composition in a ratio of 5:1 to 1:1;
• and
• wherein the pharmaceutical composition releases the naloxone and the oxycodone such that at least 87.5% of the naloxone is released from the composition over 8-12 hours.

A method of preventing oral abuse of an oral opioid pharmaceutical composition, comprising providing a therapeutically effective amount of an oral controlled release pharmaceutical composition comprising:

• oxycodone hydrochloride and a pharmaceutically acceptable salt of naloxone;
• wherein 2-40 mg of the pharmaceutically acceptable salt of naloxone is present in the pharmaceutical composition;
• wherein the oxycodone hydrochloride and the pharmaceutically acceptable salt of naloxone are present in the pharmaceutical composition in a ratio of 4:1 to 1:1;
• wherein the pharmaceutical composition further comprises a controlled release matrix that contains the oxycodone and the naloxone;
• wherein the pharmaceutical composition releases the pharmaceutically acceptable salt of naloxone and the oxycodone hydrochloride such that at least 87.5% of the pharmaceutically acceptable salt of naloxone is released from the composition over 8-12 hours.