H3 receptor antagonist for use in the treatment of alzheimer's disease
AssigneeSanofi
InventorsSophie CLAUDEL, Jeanne STEMMELIN, Pascal BARNEOUD, Philippe DELAY-GOYET, Mathilde LOPEZ-GRANCHA, Jeremy PRATT
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Abstract
The disclosure relates to the compound 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide or a pharmaceutically acceptable salt thereof, intended for the treatment of Alzheimer's disease and other types of dementia.
Claims25
A method of treating Alzheimer's disease comprising administering to a patient in need thereof a therapeutically effective amount of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide or a pharmaceutically acceptable salt thereof in combination with a cholinesterase inhibitor.
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A method of treating Alzheimer's disease in a patient on stable therapy with a cholinesterase inhibitor and in need of said treatment, comprising administering to said patient a therapeutically effective amount of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide or pharmaceutically acceptable salt thereof.
A method for the symptomatic treatment of Alzheimer's disease comprising administering to a patient in need thereof a therapeutically effective amount of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide or pharmaceutically acceptable salt thereof, wherein the treatment comprises treatment of one or more symptoms selected from the group consisting of disturbances of memory, disturbances of praxis, disturbances of attention, confusion, irritability and aggression, mood swings, language breakdown, long-term memory loss, withdrawal of the sufferer, loss of motor control, impairment of (cognitive) executive functions, functional disability, and apathy.
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Dependencies are inferred from the claim text.