Compounds for modulating trpv3 function
AssigneeHydra Biosciences, Inc.
InventorsMagdalene M. Moran, Jayhong A. Chong, Christopher Fanger, Amy Ripka, Glenn R. Larsen, Xiaoguang Zhen, Dennis John Underwood, Manfred Weigele
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Abstract
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
Claims21
1-38. (canceled)
A method for treating allergies in a subject, the method comprising administering to the subject a compound of formula I or a pharmaceutically acceptable salt, solvate, hydrate, oxidative metabolite, or prodrug thereof:
- wherein:
- R1, R2, R3, and R4 represent H or a substituent;
- X represents S or O;
- n represents 1 or 2 when X is O, or n represents 1 when X is S;
- m represents 0, 1, 2, 3, or 4;
- and
- R5 represents a substituent on the ring to which it is attached.
A method for treating a gastrointestinal disease in a subject, the method comprising administering to the subject a compound of formula I or a pharmaceutically acceptable salt, solvate, hydrate, oxidative metabolite, or prodrug thereof:
- wherein:
- R1, R2, R3, and R4 represent H or a substituent;
- X represents S or O;
- n represents 1 or 2 when X is O, or n represents 1 when X is S;
- m represents 0, 1, 2, 3, or 4;
- and
- R5 represents a substituent on the ring to which it is attached.
A method for treating an inflammatory disease or disorder in a subject, the method comprising administering to the subject a compound of formula I or a pharmaceutically acceptable salt, solvate, hydrate, oxidative metabolite, or prodrug thereof:
- wherein:
- R1, R2, R3, and R4 represent H or a substituent;
- X represents S or O;
- n represents 1 or 2 when X is O, or n represents 1 when X is S;
- m represents 0, 1, 2, 3, or 4;
- and
- R5 represents a substituent on the ring to which it is attached.
Dependencies are inferred from the claim text.