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US 2016/0256443 A1Published application
METHODS OF TREATING KERATIN HYPERPROLIFERATION DISORDERS USING mTOR INHIBITORS
AssigneeTransderm, Inc.
InventorsRoger Louis Kaspar, Robyn Patricia Hickerson
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Abstract
A method of treating or preventing keratin hyperproliferation skin disorders is set forth. The method includes the administration of an mTOR inhibitor to a subject afflicted with the hyperproliferation disorder. The mTOR inhibitor can be administered to the subject via any means known in the art including oral, topical, and transdermal administration.
Claims19
A method of treating or preventing hyperkeratosis in a subject involving overexpression or inappropriate expression of a keratin encoded for by an mRNA having a terminal oligopyrimidine (TOP) motif, comprising:
- administering to the subject a therapeutically effective amount of an mTOR inhibitor selected from the group consisting of rapamycin (sirolimus), a rapamycin analogue, a rapamycin derivative, a rapamycin prodrug, and combinations thereof.
Dependencies are inferred from the claim text.