Modulation of mrtf-a activity in pathologic fibrosis and wound healing
AssigneeThe Board of Regents of the University of Texas Sy Stem
InventorsEric M. SMALL, Eric N. OLSON
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Abstract
The present disclosure concerns uses for isoxazole compounds or salts or analogs thereof for the treatment of wounds. The present disclosure also concerns devices for delivering a isoxazole compound or salts or an analogs thereof to a wound site.
Claims70
A method of treating a wound in a subject comprising contacting said wound with a composition comprising an isoxazole or a salt or analog thereof.
A method of inhibiting pathological dermal fibrosis and/or dermal scarring in a subject comprising contacting a tissue site with a composition comprising an inhibitor of MRTF-A.
A device for the treatment of a wound in a subject comprising:
- (a) a composition comprising an isoxazole or a salt or analog thereof;
- (b) a sterile dressing into or onto which the isoxazole, salt or analog is disposed.
A suture comprising an isoxazole or a salt or analog thereof impregnated into or disposed thereon.
Dependencies are inferred from the claim text.