Halogenated esters of cyclopropanated unsaturated fatty acids for use in the treatment of neurodegenerative diseases
AssigneeBlanchette Rockefeller Neurosciences Institute
InventorsThomas J. Nelson, Daniel L. Alkon
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Abstract
The present disclosure describes novel PKC-ε activators chosen from halogenated esters of unsaturated fatty acids derivatives thereof, including halogenated esters of both polyunsaturated and monunsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.
Claims62
A compound chosen from a halogenated ester of a polyunsaturated fatty acid, monounsaturated fatty acid, or derivative thereof.
A halogenated ester of 8-[2-(2-pentylcyclopropylmethyl)-cyclopropyl]-octanoic acid (DCPLA).
A composition comprising at least one halogenated ester of a polyunsaturated fatty acid, monounsaturated fatty acid, or derivative thereof, and a pharmaceutically acceptable carrier.
A composition comprising a halogenated ester of 8-[2-(2-pentylcyclopropylmethyl)-cyclopropyl]-octanoic acid (DCPLA) and a pharmaceutically acceptable carrier.
A method for treating one or more diseases, conditions, and disorders, comprising administering to a patient in need thereof an effective amount of at least one halogenated ester of a polyunsaturated fatty acid, monounsaturated fatty acid, or derivative thereof, wherein the diseases, conditions and disorders are neurodegenerative diseases or conditions, neuroaffective disorders, stroke, mental retardation, and brain injury.
A method for treating one or more diseases, conditions, and disorders, comprising administering to a patient in need thereof an effective amount of a halogenated ester of 8-[2-(2-pentylcyclopropylmethyl)-cyclopropyl]-octanoic acid (DCPLA), wherein the diseases, conditions and disorders are neurodegenerative diseases or conditions, neuroaffective disorders, stroke, mental retardation, and brain injury.
Dependencies are inferred from the claim text.