Drugs and Gene Carrier Particles That Rapidly Move Through Mucous Barriers
AssigneeThe Johns Hopkins University
InventorsJustin Hanes, Michelle R. Dawson, Denis Wirtz, Jie Fu, Eric M. Krauland
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Abstract
The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.
Claims21
A method for treating, preventing, or diagnosing a condition in a patient, comprising administering to the patient a pharmaceutical composition comprising a polymeric particle and a pharmaceutically acceptable carrier, wherein the polymeric particle comprises a pharmaceutically acceptable polymer core, a bioactive agent, and a surface-altering agent disposed on the surface of the polymer core that renders the surface of the polymeric particle mucus resistant and/or enhances the average rate at which the particles or a fraction of the particles moves in mucus.
20-24. (canceled)
Dependencies are inferred from the claim text.