US 2016/0256386 A1Published application

Methods and compositions for localized agent delivery

AssigneeMassachusetts Institute of Technology

InventorsDarrell J. IRVINE, Matthias STEPHAN, Jaehyun MOON, Anna BERSHTEYN

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Abstract

The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.

Claims19

Dependent claims

A biodegradable nanoparticle comprising maleimide groups on its exterior surface.

Dependencies are inferred from the claim text.

Facts

Application: 15/015,464Filed 4 Feb 2016
Priority: 24 Nov 2008
Published: 8 Sep 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification41 codes

A61K 9/127
Dispersions; Emulsions: synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
A61K 38/00
Medicinal preparations containing peptides
A61K 9/146
Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried,…: with…
A61K 9/19
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: lyophilised , i.e.…

Family

Application61/200,160Us provisional application · filed 24 Nov 2008
Application13/130,845Division · filed 16 Aug 2011
Application15/015,464Division
US 2011/0293705 A1Published application
US 9,283,184 B2Related patent
US 2016/0256386 A1This patent

From the US filing history. Foreign family members aren’t listed.

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