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AssigneeThe Regents of the University of California
InventorsGarrett A. Wirth, Keyianoosh Z. Paydar, Patrick Guidotti, Donald S. Mowlds
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Fenestrated tissue grafts and acellular dermal matrices (ADMs) for use, for example, in breast reconstruction, are disclosed herein. In various embodiments, the improved tissue grafts are used in two-stage tissue expander breast reconstruction. Disclosed embodiments include altered ADMs and other tissue grafts, which comprise strategically placed fenestrations, and methods of making the same. The addition of specific patterns of fenestrations in the graft improve the breast reconstructive experience by increasing intra-operative fill volume and decreasing time to full expansion; such alterations to the graft may also increase cosmetic outcomes and patient comfort. In some embodiments, particular lengths, shapes, and measurements of overlap are used in the fenestration pattern.
A tissue graft comprising:
A tissue graft for reconstruction of a breast, the tissue graft configured to achieve desired expansion of the breast's inferior pole following attachment to a chest wall, wherein the tissue graft comprises a plurality of fenestrations disposed therein, the fenestrations causing a decrease in the effective Young's modulus of the tissue graft, and consequently yielding a larger deflection profile in accordance with the following equation:
A tissue graft for reconstruction of a breast, the tissue graft configured to achieve desired expansion of the breast's inferior pole following attachment to a chest wall, wherein the tissue graft comprises a plurality of fenestrations disposed therein, the fenestrations concentrated in a cephalic portion or caudal portion of the tissue graft such that the tissue graft has an inhomogeneous Young's modulus profile in accordance with the following equation:
Dependencies are inferred from the claim text.