Methods and Systems for Predicting Patient Responsiveness to Subcutaneous Neuromodulation Therapy as a Treatment for Hypertension

A method comprising:

• determining, by a therapy response prediction system, an index of variability of a plurality of blood pressure measurements of a patient suffering from hypertension, the plurality of blood pressure measurements recorded one at a time during waking hours of the patient during a single day, and the index of variability calculated by dividing a standard deviation of the plurality of blood pressure measurements of the patient by a square root of an average blood pressure parameter of the patient generated by averaging, over the waking hours during the single day, the plurality of blood pressure measurements of the patient;
• comparing, by the therapy response prediction system, the determined index of variability with a predetermined reference index of variability calculated by dividing a reference standard deviation by a square root of a group-averaged blood pressure parameter, the group-averaged blood pressure parameter generated by averaging a plurality of average blood pressure parameters of members of a group including a plurality of other patients suffering from hypertension;
• designating, by the therapy response prediction system if the comparing indicates that the determined index of variability is less than the predetermined reference index of variability, the patient to be within a first class of patients, the first class of patients composed of patients that are likely to be responsive to subcutaneous neuromodulation therapy as a treatment for hypertension;
• and
• designating, by the therapy response prediction system if the comparing indicates that the determined index of variability is greater than the predetermined reference index of variability, the patient to be within a second class of patients, the second class of patients composed of patients that are likely to be unresponsive to subcutaneous neuromodulation therapy as a treatment for hypertension.

A system comprising:

• at least one physical computing device that:
• determines a variability of a plurality of measurements of a cardiovascular parameter of a patient suffering from hypertension, the plurality of measurements recorded one at a time over a predetermined time period;
• compares the determined variability with a predetermined reference value;
• designates, if the comparison indicates that the determined variability is less than the predetermined reference value, the patient to be within a first class of patients, the first class of patients representative of patients that are likely to be responsive to subcutaneous neuromodulation therapy as a treatment for hypertension;
• and
• designates, if the comparison indicates that the determined variability is greater than the predetermined reference value, the patient to be within a second class of patients, the second class of patients representative of patients that are likely to be unresponsive to subcutaneous neuromodulation therapy as a treatment for hypertension.