US 2016/0252512 A1 · COMPOSITION FOR DIAGNOSING PANCREATIC CANCER AND METHOD FOR DIAGNOSING PANCREATIC CANCER USING SAME

Abstract

A composition, for diagnosing the possibility of onset of pancreatic cancer including an agent measuring the expression level of marker protein of diagnosing the possibility of onset of pancreatic cancer, or mRNA expression level of a gene encoding the protein, a kit including the composition, and a method of diagnosing pancreatic cancer using the maker are provided. The diagnostic markers of pancreatic cancer in accordance with the present disclosure are useful for predicting or diagnosing the onset, the possibility of onset, and the severity of pancreatic cancer in an early stage, and are also applied to a study on the tumorigenesis of pancreatic cancer. In addition, the diagnosis method of the present invention allows for the convenient detection of pancreatic cancer in a non-invasive manner in a sample such as blood.

Claims16

Dependent claims

A composition for diagnosing pancreatic cancer, comprising an agent for measuring a protein expression level of ABAT (4-aminobutyrate aminotransferase;

GenBank Accession No:
NP_001120920.1) protein, or a mRNA expression level of a gene coding for the ABAT protein.

A method for diagnosing pancreatic cancer, comprising:

(a) obtaining a sample from a subject to be diagnosed for the onset of pancreatic cancer;
(b) measuring a protein expression level of ABAT protein (4-aminobutyrate aminotransferase;
GenBank Accession No:
NP_001120920.1) or a mRNA expression level of a gene encoding ABAT protein;
(c) comparing the protein expression level of ABAT protein or the mRNA expression level of a gene encoding ABAT protein, with those of corresponding normal control;
and
(d) determining that the possibility of onset of pancreatic cancer is high, when the protein expression level of ABAT protein or the mRNA expression level of a gene encoding ABAT protein is higher than those of corresponding normal control in the subject, based on the comparison result in (c) step.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/901,157Filed 31 Oct 2014

Priority

KR 10-2013-013115031 Oct 2013

Published

1 Sep 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

G01N 33/57525
For cancer: of the liver or pancreas
C12Q 1/6886
For diseases caused by alterations of genetic material: for cancer
C12Q 2600/158
Oligonucleotides characterized by their use: expression markers
G01N 2333/705
From animals; from humans: assays involving receptors, cell surface antigens or cell surface determinants

Composition for diagnosing pancreatic cancer and method for diagnosing pancreatic cancer using same

Life of this patent

Composition for diagnosing pancreatic cancer and method for diagnosing pancreatic cancer using same

Life of this patent

Abstract

Claims16