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US 2016/0252471 A1Published application
Nanoparticle assisted scanning focusing x-ray fluorescence imaging and enhanced treatment
AssigneeThe Regents of the University of California
InventorsTing GUO, R. Andrew DAVIDSON
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Abstract
The present disclosure provides systems and methods for providing irradiation energy, imaging, and detecting X-ray fluorescence from a volume in a sample. The present disclosure further relates to methods of increasing the delivery of irradiation energy to a target in a sample.
Claims30
An X-ray fluorescence imaging system, the system comprising:
- a) an X-ray source configured to irradiate a sample with one or more X-ray beams, wherein the one or more X-rays beams have a defined cross-section;
- b) a detector configured to detect X-ray fluorescence;
- c) an aperture configured to define a path of detection from the irradiated sample to the detector,
- wherein the path of detection has a defined cross-section, and
- wherein the detector is configured to detect reflected X-ray fluorescence in an i-voxel formed by the area of intersection of the defined cross-section of the one or more X-ray beams and the defined cross-section of the path of detection.
2 more elements
A method of detecting a target using X-ray fluorescence imaging, the method comprising:
- a) providing a sample comprising nanoparticles, wherein the nanoparticles are configured to be associated with a target;
- b) irradiating the sample with one or more X-ray beams,
- wherein the one or more X-ray beams have a defined cross-section, and
- wherein nanoparticles in the sample contacted by the one or more X-ray beams reflect X-ray fluorescence;
- c) scanning a first i-voxel with a detector,
- wherein a path of detection is formed from the irradiated sample to the detector,
- wherein the path of detection has a defined cross-section, and
- wherein the detector is configured to detect reflected X-ray fluorescence in an i-voxel formed by the area of intersection of the defined cross-section of the one or more X-ray beams and the defined cross-section of the path of detection;
- d) scanning a second i-voxel adjacent to the first i-voxel with the detector;
- e) comparing the detection of reflected X-ray fluorescence in the first i-voxel to the detection of reflected X-ray fluorescence in the second i-voxel, and
- f) determining if the sample comprises the target.
8 more elements
A method of delivering irradiation energy to a sample, the method comprising:
- a) providing a sample comprising a t-voxel comprising an isocenter located in the interior of the sample, and a volume having equivalent volume to the t-voxel located adjacent to a surface of the sample,
- wherein the volume having equivalent volume to the t-voxel does not include the isocenter;
- b) irradiating the isocenter with one or more X-ray beams from at least three angles,
- wherein the isocenter is irradiated from at least one angle that is out of plane with at least one plane formed by two other angles,
- wherein deposition of the irradiation energy from the one or more X-ray beams is greater at the t-voxel as compared to the volume having equivalent volume to the t-voxel, wherein irradiation of the isocenter occurs for a period of time sufficient for this result to occur.
2 more elements
Dependencies are inferred from the claim text.