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US 2016/0250640 A1Published application
Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
AssigneeHandyLab, Inc.
InventorsJeff Williams, Kerry Wilson, Kalyan Handique
Life of this patent
Estimating the term…
Abstract
The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
Claims21
1-299. (canceled)
A preparatory apparatus comprising:
- one or more racks, each rack comprising a plurality of lanes, wherein each lane comprises a slot shaped and sized to receive a holder, and an aperture shaped and sized to receive a sample tube;
- a plurality of sample tubes and a plurality of holders, wherein each sample tube is removably mounted in one of the one or more racks, wherein each holder is removably mounted in one of the one or more racks adjacent to and spatially separate from a corresponding sample tube, and wherein each sample tube is configured to accept a nucleic-acid containing sample, and wherein each holder comprises a process chamber and one or more receptacles, wherein the one or more receptacles contain one or more reagents suitable for carrying out extraction of nucleic acid from a nucleic-acid containing sample;
- a magnetic separator configured to apply a magnetic force to a process chamber of a holder mounted in the rack;
- a heater assembly configured to independently heat a process chamber of a holder mounted in the rack;
- and
- a liquid dispenser configured to carry out fluid transfer operations between the plurality of sample tubes and the plurality of holders.
3 more elements
A system for preparing a plurality of samples for diagnostic testing, the system comprising:
- a rack removably mounted in the system, the rack comprising a plurality of lanes, wherein each lane comprises a slot shaped and sized to receive a holder, and an aperture shaped and sized to receive a sample tube;
- a plurality of sample tubes and a plurality of holders, wherein each sample tube is removably mounted in the rack, wherein each holder is removably mounted in the rack adjacent to and spatially separate from a corresponding sample tube, and wherein each sample tube is configured to accept a nucleic-acid containing sample, and wherein each holder comprises a process chamber and one or more receptacles, wherein the one or more receptacles contain one or more reagents suitable for carrying out extraction of nucleic acid from a nucleic-acid containing sample;
- an apparatus configured to independently heat a process chamber of a holder mounted in the rack;
- and
- a liquid dispenser configured to carry out fluid transfer operations between the plurality of holders and a microfluidic cartridge removably mounted in the system.
2 more elements
Dependencies are inferred from the claim text.