Methods and Devices for Nucleic Acid Synthesis

A nucleic acid array system comprising:

• a. one or more solid support;
• b. a plurality of discrete features associated with the one or more solid support wherein each feature comprises a plurality of support-bound oligonucleotides having a predefined sequence wherein a first support-bound oligonucleotide comprises a terminal region that is complementary to a terminal region of a second support-bound oligonucleotide, wherein a Nth support-bound oligonucleotide comprises a terminal sequence complementary to a terminal sequence region of a (N-1)th support-bound oligonucleotide, wherein N is no less than 3;
• and
• c. at least a first plurality of anchor oligonucleotides comprising a terminal sequence that is identical to a sequence region of the first support-bound oligonucleotide.

A system for producing at least one target nucleic acid, comprising:

• a. one or more solid supports having at least a first and a second features thereon, the first feature having a first plurality of support-bound oligonucleotides, the second feature having a second plurality of support-bound oligonucleotides, wherein each of the first plurality of support-bound oligonucleotides comprises a terminal sequence region complementary to that of the second plurality of support-bound oligonucleotides;
• b. an anchor support comprising a plurality of anchor oligonucleotides, each having a terminal region identical to that of the first plurality of support-bound oligonucleotides;
• and
• c. a solution of reagents for synthesizing construction oligonucleotides in a chain extension reaction using the support-bound oligonucleotides as template.