Neuronal replacement and reestablishment of axonal connections
AssigneeThe Trustees of the University of Pennsylvania
InventorsD. Kacy CULLEN, Douglas H. SMITH
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Abstract
The present invention provides compositions and methods for modulation of neuronal networks in the CNS and/or PNS. In certain embodiments, the invention includes modulation of existing networks or restoring one or more damaged or lost axonal connections. In one embodiment, the invention comprises a tissue-engineered composition comprising an elongated tubular construct having at least one neuron and axon extending through the core of the construct.
Claims46
A composition for modulating the activity of neurological network comprising:
- an elongated tubular construct having a first end and a second end, the construct comprising a tubular body having an outer surface and an inner surface defining a luminal core;
- and
- at least one axon extending through at least a portion of the core.
A method of modulating the activity of a neurological network in a subject in need thereof, the method comprising:
- providing an elongated tubular construct having a first end and a second end, the construct comprising a tubular body having an outer surface and an inner surface defining a luminal core;
- positioning at least one neuron at the first end of the construct;
- culturing the neuron with the construct in vitro to promote extension of an axon of the neuron through at least a portion of the core, thereby forming a tissue-engineered composition;
- and
- administering the tissue-engineered composition into the subject.
Dependencies are inferred from the claim text.