Absorbable Multi-Putty Bone Cements and Hemostatic Compositions and Methods of Use

A sterile composition comprising two or more separate reactive putties which can be hand mixed or kneaded together to form a homogenous settable polyurethane or polyureaurethane putty composition which hardens into its fully cured solid form at room temperature and body temperature,

• the first putty comprising one or more di- or polyisocyanates and a particulate material in amounts sufficient to produce a putty,
• the second putty comprising one or more polyols and a particulate material in amounts sufficient to produce a putty,
• such that the amount of the particulate material in the homogenous settable composition is in a range of from 45-60%, 60-70%, or 70-80% of the composition by weight,
• wherein the one or more polyols is selected from butanediol, polytetramethylene ether glycol, tris-hydroxymethyl propane, monosubstituted tris-hydroxymethyl propane, pentaerythritol, monosubstituted pentaerythritol, hydrogenated dihydroxypolyisoprene, hydroxyl terminated butadiene, hydroxyl terminated homopolymers or copolymers of ethyelene oxide and propylene oxide,
• wherein the particulate material is selected from calcium phosphate, siliconized calcium phosphate, calcium phosphate substituted with magnesium, strontium, or silicate, calcium pyrophosphate, hydroxyapatite, polymethyl methacrylate, glass-ionomer, absorbable phosphate glass, calcium sulfate, tricalcium phosphate, or any combination thereof, and
• each putty optionally and independently comprises one or more additive components.