Deuterated compounds and uses thereof

A deuterated compound of formula (I) or formula (V):

• or a salt thereof, wherein:
• R1 is phenyl, naphthyl, 6-membered heteroaryl, 9- or 10-membered bicyclic heterocyclyl, 12-13 membered tricyclic carbocyclyl, or 12-13 membered tricyclic heterocyclyl, wherein R1 is optionally substituted with one or more groups Ra, wherein R1 is attached to the remainder of the compound of formula (I) at any synthetically feasible position;
• A is absent, C1-4alkylene, C3-6cycloalkylene, C2-4alkenylene, or C2-4alkynylene;
• R2 is 6-, 9-, or 10-membered carbocyclyl or a 5-, 6-, 9-, or 10-membered heterocyclyl, which carbocyclyl and heterocyclyl is optionally substituted with one or more groups Rb, wherein R2 is attached to the remainder of the compound of formula (I) at any synthetically feasible position;
• each X10-X17 is independently CH or N;
• X18 is CH, N, O, or S;
• and
• X19 is CH, C, or N;
• each ---- is independently absent or forms a double bond, provided only one ---- forms a double bond;
• each Ra is independently selected from oxo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, —(O—CH2—CH2)m—Rc, carbocyclyl, heterocyclyl, halo, —NO2, —N(Rv)2, —CN, —C(O)—N(Rv)2, —S(O)—N(Rv)2, —S(O)2—N(Rv)2, —O—C(O)—Rv, —O—C(O)—O—Rv, —C(O)—Rv, —C(O)—O—Rv, —S(O)—Rv, —S(O)2—Rv, —O—C(O)—N(Rv)2, —N(Rv)—C(O)—ORv, —N(Rv)—C(O)—N(Rv)2, —N(Rv)—C(O)—Rv, —N(Rv)—S(O)—Rv, —N(Rv)—S(O)2—Rv, —N(Rv)—S(O)—N(Rv)2, and —N(Rv)—S(O)2—N(Rv)2, wherein any C1-6alkyl, C2-6alkenyl, C2-6alkynyl, —(O—CH2—CH2)m—Rc, carbocyclyl, and heterocyclyl is optionally substituted with one or more groups independently selected from oxo, halo, —NO2, —N(Rv)2, —CN, —C(O)—N(Rv)2, —S(O)—N(Rv)2, —S(O)2—N(Rv)2, —S—Rv, —O—C(O)—Rv, —C(O)—Rv—S(O)2—Rv, —C(O)—N(Rv)2, —N(Rv)—C(O)—Rv, —N(Rv)—S(O)—Rv, —N(Rv)—S(O)2—Rv, C2-C6 alkenyl, Ray, and C1-6alkyl that is optionally substituted with one or more groups independently selected from oxo and halo;
• each Rb is independently selected from oxo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, —(O—CH2—CH2)m—Rd, carbocyclyl, heterocyclyl, halo, —NO2, —N(Rw)2, —CN, —C(O)—N(Rw)2, —S(O)—N(Rw)2, —S(O)2—N(Rw)2, —O—Rw, —S—Rw, —O—C(O)—Rw, —O—C(O)—O—Rw, —C(O)—Rw, —C(O)—O—Rw, —S(O)—Rw, —S(O)2—Rw, —O—C(O)—N(Rw)2, —N(Rw)—C(O)—ORw, —N(Rw)—C(O)—N(Rw)2, —N(Rw)—C(O)—Rw, —N(Rw)—S(O)—Rw, —N(Rw)—S(O)2—Rw, —N(Rw)—S(O)—N(Rw)2, and —N(Rw)—S(O)2—N(Rw)2, wherein any C1-6alkyl, C2-6alkenyl, C2-6alkynyl, —(O—CH2—CH2)m—Rd, carbocyclyl, and heterocyclyl is optionally substituted with one or more groups independently selected from oxo, halo, —NO2, —N(Rw)2, —CN, —C(O)—N(Rw)2, —S(O)—N(Rw)2, —S(O)2—N(Rw)2, —O—Rw, —S—Rw, —O—C(O)—Rw, —C(O)—Rw, —C(O)—O—Rw, —S(O)—Rw, —S(O)2—Rw, —C(O)—N(Rw)2, —N(Rw)—C(O)—Rw, —N(Rw)—S(O)—Rw, —N(Rw)—S(O)2—Rw, C2-C6 alkenyl, Ry, and C1-6alkyl that is optionally substituted with one or more groups independently selected from oxo and halo;
• each Rc is independently selected from hydrogen, halo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl and heterocyclyl is optionally substituted with one or more groups independently selected from halo, hydroxy, and C1-6alkoxy;
• each Rd is independently selected from hydrogen, halo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl and heterocyclyl is optionally substituted with one or more groups independently selected from halo, hydroxy, and C1-6alkoxy;
• each Rv is independently selected from hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl, wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl is optionally substituted with one or more groups independently selected from oxo, cyano, nitro, halo, —N(Rax)2, —ORax, C2-C6 alkenyl, Ray, and C1-C6 alkyl that is optionally substituted with one or more groups independently selected from oxo and halo;
• or two Rv are taken together with the nitrogen to which they are attached to form a heterocyclyl that is optionally substituted with one or more groups independently selected from oxo, halo and C1-3alkyl that is optionally substituted with one or more groups independently selected from oxo and halo;
• each Rw is independently selected from hydrogen, C1-6alkyl, C2 alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl, wherein each C1-6alkyl, C2 alkenyl, C2-6alkynyl, carbocyclyl, and heterocyclyl is optionally substituted with one or more groups independently selected from oxo, cyano, nitro, halo, —N(Rx)2, —ORx, C2-C6 alkenyl, Ry, and C1-C6 alkyl that is optionally substituted with one or more groups independently selected from oxo and halo;
• or two Rw are taken together with the nitrogen to which they are attached to form a heterocyclyl that is optionally substituted with one or more groups independently selected from oxo, halo and C1-3alkyl that is optionally substituted with one or more groups independently selected from oxo and halo;
• each Rx is independently selected from hydrogen and C1-6alkyl;
• each Rax is independently selected from hydrogen and C1-6alkyl;
• each Ry is aryl that is optionally substituted with one or more groups independently selected from halo, hydroxyl, cyano, nitro, amino, —O—S(O)2—Rz, —OSi(Rz)3, and —O-(heterocyclyl);
• each Ray is aryl that is optionally substituted with one or more groups independently selected from halo, hydroxyl, cyano, nitro, amino, —O—S(O)2—Raz, —OSi(Raz)3, and —O-(heterocyclyl);
• each Rz is independently selected from C1-6alkyl and aryl;
• each Raz is independently selected from C1-6alkyl and aryl;
• each m is 1, 2, 3, 4, or 5;
• and
• each n is 1, 2, 3, 4, or 5;
• wherein the compound of formula (I) and formula (V) optionally comprises one or more imaging isotopes;
• wherein one or more carbon atoms of the compound of formula (I) and formula (V) is deuterated;
• and
• wherein the compound of formula (V) is substituted with one or more groups Ra.