US 2016/0250346 A1Published application

Pyrrolobenzodiazepine-antibody conjugates

AssigneesMedImmune, LLC, Adc Therapeutics SA

InventorsPhilip Wilson Howard, Patricius Hendrikus Cornelis Van Berkel

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Abstract

Conjugates of specific PBD dimers with an antibody that binds to CD22, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.

Claims15

Dependent claims

A conjugate of formula

wherein:
Ab is an antibody that binds to CD22, the antibody comprising a VH domain having the sequence according to SEQ ID NO. 1.

Dependencies are inferred from the claim text.

Facts

Application: 15/028,591Filed 10 Oct 2014
Priority: GB 1317981.711 Oct 2013
Published: 1 Sep 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 31/5517
1,4-Benzodiazepines, e.g. diazepam or clozapine: condensed with five-membered rings having nitrogen as a ring hetero atom, e.g.…
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 47/68035
Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates: the drug being a pyrrolobenzodiazepine
A61K 47/6849
The modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site: the antibody targeting a receptor, a cell…

Family

US 9,956,299 B2Related patent
US 2016/0250346 A1This patent

From the US filing history. Foreign family members aren’t listed.

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