Pegylated Artesunate Derivative, Pharmaceutical Composition and Use Thereof

An artesunate-polyethylene glycol derivative as shown in Formula (I),

• wherein,
• POLY represents a polyethylene glycol residue with a molecular weight of 200 to 100,000 Da;
• X represents amino or oxygen atom or methoxy;
• Y represents a compound with amino acid structure containing two amino groups and one carboxyl, wherein the carboxyl together with X of POLY form an amide bond or ester bond, while the multiple amino groups in the introduced distal end and the carboxyl of artesunate form amide bonds;
• n and m represents polymerization degree of Y, m and n independently are an integer of 0 to 12;
• r and s represents polymerization degree of artesunate;
• and
• when neither m nor n is 0, r and s separately are the double of n and m, and artesunate via carboxyl forms an amide bond with the multiple amino groups introduced by Y;
• when m is 0 and n is not 0, or m is not 0 and n is 0, r and s separately are the double of n and m, and artesunate via carboxyl forms amide bonds with the multiple amino groups introduced by Y, and X at the end where m is 0 or n is 0 is methoxy;
• or
• when both m and n are 0, both r and s are 1, artesunate via carboxyl forms an ester or an amide with X.