Acetylcysteine Compositions and Methods of use Thereof

A method of treatment, comprising intravenously administering a 300 mg/kg dose of acetylcysteine to a patient in need of treatment with acetylcysteine over 20 hours via a 2-bag infusion regimen comprising a first dose of 200 mg/kg delivered over a time period from about 3 to about 5 hours, followed by a second dose of 100 mg/kg over 16 hours.

An improvement in a method of intravenously administering a 300 mg/kg dose of acetylcysteine to a patient in need of treatment with acetylcysteine over 20 hours, the improvement comprising decreasing the initial rate of acetylcysteine infusion to 50 mg/kg per hour and maintaining that rate of infusion for 4 hours.

A pharmaceutical composition, consisting of comprising 6 g acetylcysteine, an effective amount of sodium hydroxide to provide a pH in the range from about 6.0 to about 7.5, and a sufficient amount of sterile water for injection, USP to provide a total volume of 30 mL (200 mg/mL).

A pharmaceutical composition, consisting of an amount of acetylcysteine effective to provide a dose of 200 mg per kg of weight of a human patient, an effective amount of sodium hydroxide to provide a pH in the range from about 6.0 to about 7.5, sterile water for injection, in 1000 mL 0.45% Sodium Chloride Injection.

A pharmaceutical composition, consisting of an amount of acetylcysteine effective to provide a dose of 100 mg per kg of weight of a human patient, an effective amount of sodium hydroxide to provide a pH in the range from about 6.0 to about 7.5, sterile water for injection, in 500 mL 0.45% Sodium Chloride Injection.

A pharmaceutical composition, consisting of an amount of acetylcysteine effective to provide an effective dose of acetylcysteine to a human patient, an effective amount of sodium hydroxide to provide a pH in the range from about 6.0 to about 7.5, sterile water for injection, and sodium chloride.