Upconverting nanoparticles
OwnerAmol Punjabiinventor
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Abstract
Provided herein are lanthanide-containing upconverting nanoparticles, methods of their preparation, compositions, and methods of using the same. The polymers and compositions provided herein may be used, for example, in photodynamic therapy.
Claims19
A nanoparticle comprising a rare earth metal fluoride composition according to the formula M1M2F4 comprising lanthanide ions, wherein M1 is the alkali metal, M2 is the rare earth, and wherein the composition comprises:
- ytterbium in an amount from about 70 mol % to about 99 mol % of the rare earth present in the composition;
- erbium in an amount from about 0.1 mol % to about 10 mol % of the rare earth present in the composition;
- and
- yttrium in an amount from about 0 mol % to about 30 mol % of the rare earth present in the composition.
A method of preparing an upconverting nanoparticle comprising reacting in a reaction mixture rare earth trifluoroacetates and sodium trifluoroacetate under conditions sufficient to form a sodium rare earth trifluoroacetate, wherein the rare earth trifluoroacetates are selected from the group consisting of:
- ytterbium trifluoroacetate in an amount from about 70 mol % to about 99 mol % of the rare earth trifluoroacetates present in the reaction mixture;
- erbium trifluoroacetate in an amount from about 0.1 mol % to about 10 mol % of the rare earth trifluoroacetates present in the reaction mixture;
- and
- yttrium trifluoroacetate in an amount from about 0.1 mol % to about 10 mol % of the rare earth trifluoroacetates present in the reaction mixture.
Dependencies are inferred from the claim text.