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US 2016/0250320 A1Published application
Immunoregulatory peptides and methods of use
Assignee13 Therapeutics, Inc.
InventorsSharon L. McCoy, Steven H. Hefeneider
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Abstract
Peptides for the treatment of inflammation, and therapeutic uses and methods of using the same are disclosed. Peptides including a transducing sequence are effective for inhibiting cytokine activity and TNF-α secretion through interaction with toll-like receptors. Experiments are described illustrating the efficacy of the compounds in treating otitis media.
Claims20
1-44. (canceled)
A pharmaceutical peptide composition comprising:
- a peptide-transducing sequence conjugate, wherein the peptide comprises SEQ ID NO.:
- 327, SEQ ID NO.:
- 368, SEQ ID NO.:
- 352, SEQ ID NO.:
- 367, or SEQ ID NO.:
- 353;
- and wherein the peptide is conjugated to a transducing sequence at the peptide C-terminus;
- and a pharmaceutically-acceptable excipient, wherein the pharmaceutical composition is in a unit dosage form.
5 more elements
A method of treating inflammation in an animal in need thereof, the method comprising:
- administering to the animal in need thereof a therapeutically-effective amount of a peptide-transducing sequence conjugate, wherein the peptide comprises SEQ ID NO.:
- 327, SEQ ID NO.:
- 368, SEQ ID NO.:
- 352, SEQ ID NO.:
- 367, or SEQ ID NO.:
- 353;
- and wherein the peptide is conjugated to a transducing sequence at the peptide C-terminus, wherein the pharmaceutical composition is in a unit dosage form.
4 more elements
A method of treating hearing impairment in an animal, the method comprising:
- administering a therapeutically-effective amount of a peptide-transducing sequence conjugate, wherein the peptide comprises SEQ ID NO.:
- 327, SEQ ID NO.:
- 368, SEQ ID NO.:
- 352, SEQ ID NO.:
- 367, or SEQ ID NO.:
- 353;
- and wherein the peptide is conjugated to a transducing sequence at the peptide C-terminus, to an animal having middle and/or inner ear inflammation and reduced hearing.
4 more elements
Dependencies are inferred from the claim text.