Schmallenberg virus (sbv) vaccine, methods of production, and uses thereof

A method of treating or preventing SBV in an animal in need of said treatment comprising administering to said animal a therapeutically effective amount of an immunogenic composition comprising an aziridine compound-inactivated Schmallenberg virus (SBV), wherein the inactivated SBV comprises a medium (M) RNA segment having a sequence that is inverse complementary to a nucleic acid sequence having at least 95% sequence identity with the nucleic acid sequence of SEQ ID NO:2 over the whole length of SEQ ID NO:2.

A method of treating or preventing viremia or malformations induced by SBV comprising administering to said animal a therapeutically effective amount of an immunogenic composition comprising an aziridine compound-inactivated Schmallenberg virus (SBV), wherein the inactivated SBV comprises a medium (M) RNA segment having a sequence that is inverse complementary to a nucleic acid sequence having at least 95% sequence identity with the nucleic acid sequence of SEQ ID NO:2 over the whole length of SEQ ID NO:2.

A method for inducing an immune response against SBV in a herd of animals comprising the step of administering an immunogenic composition comprising an aziridine compound-inactivated Schmallenberg virus (SBV), wherein the inactivated SBV comprises a medium (M) RNA segment having a sequence that is inverse complementary to a nucleic acid sequence having at least 95% sequence identity with the nucleic acid sequence of SEQ ID NO:2 over the whole length of SEQ ID NO:2.

A method for preventing or reducing viremia or malformations induced by SBV in a herd of animals comprising the step of administering an immunogenic composition comprising an aziridine compound-inactivated Schmallenberg virus (SBV), wherein the inactivated SBV comprises a medium (M) RNA segment having a sequence that is inverse complementary to a nucleic acid sequence having at least 95% sequence identity with the nucleic acid sequence of SEQ ID NO:2 over the whole length of SEQ ID NO:2.

A method for preventing or reducing the transmission of SBV in a herd of animals comprising the step of administering an immunogenic composition comprising saponin, aluminum hydroxide, and an aziridine compound-inactivated Schmallenberg virus (SBV), wherein the inactivated SBV comprises a medium (M) RNA segment having a sequence that is inverse complementary to a nucleic acid sequence having at least 95% sequence identity with the nucleic acid sequence of SEQ ID NO:2 over the whole length of SEQ ID NO:2.