Polyvalent conjugate vaccine for cancer
AssigneeSloan-Kettering Institute for Cancer Research
InventorsPhilip O. Livingston, Govindaswami Ragupathi, Samuel J. Danishefsky
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AssigneeSloan-Kettering Institute for Cancer Research
InventorsPhilip O. Livingston, Govindaswami Ragupathi, Samuel J. Danishefsky
Estimating the term…
This invention provides a polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated mucin antigen and an appropriate adjuvant. This invention also provides a multivalent vaccine comprising at least two of the following: glycosylated MUC-1-32mer, Globo H, GM2, Ley, Tn(c), sTN(c), and TF(c). This invention provides the vaccine above, wherein the adjuvant is saponin-based adjuvant. This invention provides a method for inducing immune response in a subject comprising administering an effective amount of the vaccine above to the subject. Finally, this invention provides a method for treating cancer in a subject comprising administering an appropriate amount of the vaccine above to the subject.
A polyvalent vaccine comprising at least two conjugated antigens selected from a group containing glycolipid antigen, polysaccharide antigen, mucin antigen, glycosylated mucin antigen and an appropriate adjuvant.
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A method for treating cancer in a subject comprising administering an immunogenic composition comprising an adjuvant and antigens comprising MUC1-Tn conjugate, GloboH, TF(c) and at least one antigen selected from the group consisting of GM2, sTn(c) and sialyl Lea, wherein said conjugate and each of said antigens are individually conjugated to a carrier.
Dependencies are inferred from the claim text.