Loading patent…
AssigneeKorea Advanced Institute of Science and Technology
InventorsJin Woo Kim, Nam-Suk Kim
Estimating the term…
The present invention relates to a pharmaceutical composition for the regeneration of nerves comprising Vax protein as an active ingredient. Vax1 is secreted in the ventral hypothalamus (vHT) explant separated from a mouse. The secreted Vax1 combines with extracellular sugar group of heparan sulfate proteoglycans (HSPGs) existing in retinal ganglion cell (RGC) axon of the retinal explant co-cultured so as for the complex invades into axonplasm. Then, the Vax1 conjugated with the sugar group activates the local protein synthesis to accelerate the growth of retinal ganglion cell axon. In some embodiments, Vax protein or a nucleic acid encoding the protein, can be used in a pharmaceutical composition for the regeneration of nerves.
A method for regenerating a nerve and/or accelerating the growth of axons comprising administering to a subject a pharmaceutically effective dose of Vax protein to a subject having neuronal and axonal damage, or administering to the subject a pharmaceutically effective dose of a vector or cell comprising a polynucleotide encoding the Vax protein, thereby regenerating nerves and/or accelerating the growth of axons in the subject.
A method for screening candidate materials for regenerating nerves and/or accelerating the growth of axons comprising:
Dependencies are inferred from the claim text.