Compositions and methods for prophylaxis and therapy of clostridium difficile infection
AssigneeThe Rockefeller University
InventorsChandrabali GHOSE-PAUL, David H. HO
Life of this patent
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Abstract
Provided are compositions and methods for prophylaxis and/or therapy of C. difficile infection, and for inhibiting dissemination of C. difficile spores. The compositions contain C. difficile proteins, including distinct proteins and fusions of C. difficile CD 1067, BclA1, SleC, CotA, Spl7, FliC, FliD, CD toxin A, CD toxin B, and combinations thereof. The methods include prophylaxis and/or therapy of C. difficile infection by administering to a subject in need a composition that includes the C. difficile protein(s).
Claims17
A method for prophylaxis and/or therapy of Clostridium difficile (C. difficile) infection comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising at least one Clostridium difficile (C. difficile) polypeptide, wherein the C. difficile polypeptide is selected from the group consisting of CD1067, BclA1, SleC, CotA, Spl7, and combinations thereof.
A pharmaceutical composition comprising a Clostridium difficile (C. difficile) polypeptide selected from the group consisting of CD1067, BclA1, SleC, CotA, Spl7, and combinations thereof, for use in prophylaxis and/or therapy of C. difficile infection.
An article of manufacture comprising a pharmaceutical composition comprising packaging, and comprising a Clostridium difficile (C. difficile) polypeptide selected from the group consisting of CD1067, BclA1, SleC, CotA, Spl7, and combinations thereof, in a sealed container, wherein the pharmaceutical composition is a cell free composition, and wherein the packaging comprises printed material, and wherein the printed material provides an indication that the pharmaceutical composition is to be used for prophylaxis and/or treatment of C. difficile infection.
Dependencies are inferred from the claim text.