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US 2016/0250260 A1Published application
Small molecule cellular reprogramming to generate neuronal cells
AssigneeThe J. David Gladstone Ins., a testamentary trust established under the Will of J. David Gladstone
InventorsChangsheng Lin, Sheng Ding
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Abstract
Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become neuronal cells.
Claims24
A composition comprising the following agents:
- a GSK3 inhibitor, an ALK4/5/7 inhibitor, an HDAC inhibitor, and a p300 activator.
(canceled)
A composition comprising the following compounds:
- a ROCK inhibitor, a neuronal differentiation enhancer, an omega-3 fatty acid, an A3 adenosine receptor agonist, and an L-type calcium channel blocker.
(canceled)
Dependencies are inferred from the claim text.