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US 2016/0250205 A1Published application
Process for preparing oxycodone compositions
AssigneesPurdue Pharma L.P., The P.F. Laboratories, Inc., Purdue Pharmaceuticals L.P., Rhodes Technologies
InventorsRobert Chapman, Lonn S. Rider, Qi Hong, Donald Kyle, Robert Kupper
Life of this patent
Estimating the term…
Abstract
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Claims31
1-79. (canceled)
A process for preparing an oxycodone salt composition, which process comprises:
- combining (i) an oxycodone free base composition comprising a first amount of 14-hydroxycodeinone and (ii) an acid under conditions to provide an oxycodone salt composition comprising a second amount of 14-hydroxycodeinone, the second amount of 14-hydroxycodeinone being lower than the first amount of 14-hydroxycodeinone.
A process for preparing an oxycodone composition, which process comprises steps of:
- (a) preparing a mixture comprising a first oxycodone composition and an acid, the first oxycodone composition comprising a first amount of 14-hydroxycodeinone;
- and
- (b) incubating the mixture to provide a second oxycodone composition comprising a second amount of 14-hydroxycodeinone, the second amount of 14-hydroxycodeinone being lower than the first amount of 14-hydroxycodeinone.
A process for preparing an oxycodone composition, which process comprises steps of:
- (a) providing a solution comprising a first oxycodone composition comprising 8α,14-dihydroxy-7,8-dihydrocodeinone and a first amount of 14-hydroxycodeinone;
- (b) controlling an acid catalyzed dehydration consisting of conversion of 8α,14-dihydroxy-7,8-dihydrocodeinone to 14-hydroxycodeinone in the solution to provide a second oxycodone composition comprising a second amount of 14-hydroxycodeinone, the second amount of 14-hydroxycodeinone being lower than the first amount of 14-hydroxycodeinone;
- and
- (c) isolating the second oxycodone composition comprising the second amount of 14-hydroxycodeinone.
1 more element
A process for preparing an oxycodone salt composition, which process comprises:
- combining (i) an oxycodone free base composition comprising 8α,14-dihydroxy-7,8-dihydrocodeinone and an amount of 14-hydroxycodeinone and (ii) an acid under conditions to provide an oxycodone salt composition comprising a decreased amount of 14-hydroxycodeinone.
Dependencies are inferred from the claim text.