Production method of pharmaceutical composition containing candesartan cilexetil

Abstract

A production method of pharmaceutical composition contains candesartan cilexetil, comprising dissolving a water-soluble polymer and a sugar alcohol to purified water and dispersing candesartan cilexetil to prepare a dispersion liquid of candesartan cilexetil, granulating by a wet process using the dispersion liquid together with a powdery additive to obtain a granulated product, drying the granulated product, particle size regulating the granulated product; and tableting the granulated product, wherein the dispersion liquid contains the amount of water-soluble polymer within a range of 0.05 parts by weight or more and 0.5 parts by weight or less, based on 100 parts by weight of the pharmaceutical composition, and the dispersion liquid contains the amount of sugar alcohol within a range of 5 parts by weight or more and 20 parts by weight or less, based on 100 parts by weight of the pharmaceutical composition.

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