Esters of short chains fatty acids for use in the treatment of immunogenic disorders

A pharmaceutical composition comprising a compound of formula (1)

• wherein
• X is —O—;
• R and R2 are hydrogen and R1 is selected from the group consisting of methyl, ethyl, and hydroxyethyl;
• or
• R is selected from the group consisting of methyl, ethyl, propyl, benzyl, nitrobenzyl, and polyethylene glycol, R1 is methyl, and R2 is hydrogen;
• or
• a pharmaceutically acceptable salt thereof, wherein the compound is formulated for transmucosal administration.

A method for the prevention, attenuation or treatment of a disease or disorder associated with a compromised Th1 immune response, an unwanted Th2 or Th2 like immune response, or both, comprising administering to a subject in need thereof transmucosally a compound of formula (I)

• wherein
• X is —O—, —S—, or —NH—;
• R is selected from the group consisting of hydrogen, methyl, ethyl, propyl, benzyl, nitrobenzyle, and polyethylene glycol;
• R1 is selected from the group consisting of methyl, ethyl, and hydoxyethyl;
• and
• R2 is hydrogen;
• or
• a pharmaceutically acceptable salt thereof.