Targeted capsules for the delivery of skin whitening agents in the skin

A microcapsule or nanocapsule comprising a skin whitening compound selected from the group consisting of arbutin, vitamin C, ascorbyl phosphate, niacinamide, dynachondrine, a tyrosinase inhibitor peptide, tretinoin, hydroquinone, kojic acid and esters thereof with fatty acids, azelaic acid, glutathione, cinnamomum subavenium extracts, alpha-hydroxy acids such as lactic acid or glycolic acid, ferulic acid, vitamin E, ellagic acid, Dome grate extracts and mixtures thereof and a peptide of formula (I):

• (I)
• R2-Ser1-Tyr2-Ser3-Nle4-Glu5-His6-DPhe7-Arg8-(AA1)9-
• Gly10-Lys11-DPro12-Val13-R1
• wherein
• R1, is selected from the group consisting of —OH, —OR3, —SR3, —NR3R4, —NHR9, polyethylene glycol or a derivative thereof and —OR9 wherein R9 is polyethylene glycol or a derivative thereof;
• R2, is selected from the group consisting of H—, R3—C(O)— and R3—OC(O)—,
• R3 and R4 are independently selected from H, C1-C24 alkyl, C2-C24 alkenyl and C6-C10 aryl;
• AA1, is selected from the amino acid groups that represents an aromatic amino acid group;
• and cosmetically acceptable salts and solvates thereof,
• coupled to the outer surface of the microcapsule or nanocapsule.