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US 2016/0243538 A1Published application
Chromatography Membranes Formed by Thiol-Ene or Thiol-Yne Click Polymerization Reactions
AssigneeNatrix Separations Inc.
InventorsAmro Ragheb, Gary Skarja
Life of this patent
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Abstract
Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
Claims20
A composite material, comprising:
- a support member, comprising a plurality of pores extending through the support member;
- and
- a cross-linked gel, wherein the cross-linked gel comprises a polymer derived from a first monomer and a first cross-linker;
- wherein
- the cross-linked gel is located in the pores of the support member;
- the first monomer comprises two thiol functional groups;
- and
- the first cross-linker comprises (i) at least three carbon-carbon double bonds, (ii) at least two carbon-carbon triple bonds, or (iii) at least one carbon-carbon triple bond and at least one carbon-carbon double bond.
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A method of making a composite material, comprising the steps of:
- combining a first monomer, a first cross-linker, a photoinitiator, and a solvent, thereby forming a monomeric mixture;
- wherein the first monomer comprises two thiol functional groups;
- and the first cross-linker comprises (i) at least three carbon-carbon double bonds, (ii) at least two carbon-carbon triple bonds, or (iii) at least one carbon-carbon triple bond and at least one carbon-carbon double bond;
- contacting a support member with the monomeric mixture, thereby forming a modified support member;
- wherein the support member comprises a plurality of pores extending through the support member;
- and the average pore diameter of the pores is about 0.1 to about 25 μm;
- covering the modified support member with a polymeric sheet, thereby forming a covered support member;
- and
- irradiating the covered support member for a period of time, thereby forming the composite material.
6 more elements
Dependencies are inferred from the claim text.