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AssigneesExmoor Pharma Concepts Ltd, Lonza Biologics PLC, UCL Business PLC, Amercare Ltd
InventorsJohn Vincent, Rui Tostoes, Farlan Veraitch, John Dodgson
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The present invention provides devices, apparatus and systems suitable for achieving volume reduction in a liquid containing a species in suspension and methods of use thereof. The apparatus of the invention comprises (i) a filter device comprising: a tubular first chamber having a filter provided in a surface thereof, a second chamber in fluid communication with the first chamber through the filter, the device being provided with an inlet port opening to the first end of the first chamber, an outlet port opening to the second end of the first chamber, and a filtrate port opening to the second chamber, and (ii) a fluidic pathway from the outlet port, wherein the apparatus is configured to introduce the first liquid and a second fluid immiscible with the first to the first chamber and the apparatus comprises a flow cut-off means in the fluidic pathway from the outlet port.
Apparatus for filtration of a fret liquid comprising a species in suspension, comprising:
Apparatus according to any preceding claim wherein the inlet port is configured to receive both the first liquid and the second immiscible fluid.
Apparatus according to any preceding claim further comprising a control means configured to set the flow cut-off means in one of a first condition in which flow along the outlet fluidic pathway is prevented and a second condition in which such flow is permitted.
Apparatus according to any of claims 5 to 8 further comprising a suspension inlet fluidic pathway comprising a suspension inlet valve and a second fluid inlet fluidic pathway comprising a second fluid inlet valve, the said fluidic pathways being connected to the first chamber, wherein the control means is configured to control the cut-off valve and one or both of the suspension inlet valve and the second fluid inlet valve.
Apparatus according to any preceding claim comprising a reservoir of a second fluid immiscible with the first liquid in fluid communication with a port opening to the first chamber.
Apparatus according to any preceding claim wherein the second immiscible fluid is a gas.
Apparatus according to any preceding claim wherein the filter device comprises the cutoff valve.
Apparatus according to any preceding claim wherein the cut-off waive is a check valve.
Apparatus according to any preceding claim wherein the cutoff valve is in close connection to the first chamber.
Apparatus according to any preceding claim further comprising a reservoir of a third liquid miscible with the first liquid in fluid communication with the inlet or the outlet port.
Apparatus according to any preceding claim wherein the first chamber has a substantially circular cross section and the filter is disposed in the surface forming the periphery of the first chamber.
Apparatus according to any preceding claim wherein the filter device comprises a plurality of first chambers.
Apparatus according to any preceding claim wherein a first chamber comprises a region having impermeable waits adjacent to the outlet of the chamber.
Apparatus according to any preceding claim wherein a wall of the first chamber is inclined downwards towards the outlet port at an angle to the horizontal.
Apparatus according to any preceding claim comprising one or more further ports opening to the first chamber at a position between the inlet pert and the outlet port.
Apparatus according to any preceding claim wherein the outlet port of the first chamber is connected to a collection device.
A system for processing a liquid containing a species in suspension comprising apparatus according to an preceding claim and a source of liquid containing the species in fluid communication with the inlet of the filter device.
Dependencies are inferred from the claim text.