Inhalable medicament
AssigneeTeva Branded Pharmaceutical Products R&D, Inc.
InventorsMukul DALVI, Libo WU
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Abstract
The present invention provides a solution formulation for inhalation comprising: a liquid phase; an active ingredient containing a carboxylic ester in which the oxygen atom is covalently bound to a quaternary nitrogen-containing heterocycle, dissolved in the liquid phase; and a magnesium or calcium salt, dissolved in the liquid phase. The formulation is particularly suited to pMDIs and nebulisers.
Claims25
A solution formulation for inhalation comprising:
- a liquid phase;
- an active ingredient containing a carboxylic ester in which the oxygen atom is covalently bound to a quaternary nitrogen-containing heterocycle, dissolved in the liquid phase;
- and
- a magnesium salt, dissolved in the liquid phase.
A method of stabilizing an active ingredient containing a carboxylic ester in which the oxygen atom is covalently bound to a quaternary nitrogen-containing heterocycle, wherein the active ingredient is present in a solution formulation for inhalation, the method comprising formulating the solution formulation using at least one magnesium salt.
Dependencies are inferred from the claim text.