Cmv immuno-stimulatory composition

The nucleic acid of any one of the preceding claims wherein the first region includes an attenuation of a CMV gene that prevents replication of the CMV or viral particle translated from the first region in an infected cell.

The nucleic acid of any one of the preceding claims wherein the first region includes an attenuation that prevents infection of a bystander cell in the form a cell adjacent the infected cell, by a CMV or viral particle translated from the first region.

The nucleic acid of any one of the preceding claims wherein the first region includes an attenuation of a CMV gene that regulates expression of host MHC Class I or II genes.

The nucleic acid of any one of the preceding claims wherein the first region includes a mutation for modifying the immunogenicity of the CMV or viral particle encoded by the first region.

The nucleic acid of any one of the preceding claims wherein the first region includes one or more genes encoding a non CMV epitope.

The nucleic acid of any one of the preceding claims wherein the second region encodes a cytokine in the form of an interferon Type I (IFNI).

The nucleic acid of any one of the preceding claims wherein the second region encodes a further cytokine for preventing a CMV or viral particle translated from the first region from infecting a cell.

The nucleic acid of anyone of the preceding claims wherein the first region is linked to the second region thereby encoding a fusion protein in the form of a CMV peptide or viral particle peptide encoded by the first region that is linked to the cytokine encoded by the second region.

A vector including a nucleic acid of any one of the preceding claims.

A virus or infective particle including a nucleic acid of any one of the preceding claims.

A cell including a nucleic acid, vector, or virus of any one of the preceding claims.

A composition including a nucleic acid, vector, virus or cell of any one of the preceding claims.

A method for treating an individual having a CMV infection including the step of:

• administering a nucleic acid of any one of the preceding claims to an individual having a CMV infection, thereby treating the individual for CMV infection.

A method for preventing an individual from infection with CMV including the step of:

• administering a nucleic acid of any one of the preceding claims to an individual in whom CMV infection is to be prevented, thereby treating the individual for CMV infection.